Learned helplessness in flies and the roots of depression
When faced with impossible circumstances beyond their control, animals, including humans, often hunker down as they develop sleep or eating disorders, ulcers, and other physical manifestations of depression. Now, researchers reporting in the Cell Press journal Current Biology on April 18 show that the same kind of thing happens to flies.
The study is a step toward understanding the biological basis for depression and presents a new way for testing antidepressant drugs, the researchers say. The discovery of such symptoms in an insect shows that the roots of depression are very deep indeed.
“Depressions are so devastating because they go back to such a basic property of behavior,” says Martin Heisenberg of the Rudolf Virchow Center in Würzburg, Germany.
Heisenberg says that the idea for the study came out of a lengthy discussion with a colleague about how to ask whether flies can feel fear. Franco Bertolucci, a coauthor on the study, had found that flies can rapidly learn to suppress innate behaviors, a phenomenon that is part of learned helplessness.
The researchers now show that flies experiencing uncomfortable levels of heat will walk to escape it. But if the flies realize that the heat is beyond their control and can’t be avoided, they will stop responding, walking more slowly and taking longer and more frequent rests, as if they were “depressed.”
Intriguingly, female flies slow down more under those stressful circumstances than males do. It’s not clear exactly what that means, but Heisenberg explains, “if we realize that the fly trapped in a strange, dark box, unable to get rid of the dangerous heat pulses, has to find a compromise between saving energy and not missing any chance of escape, we can understand that such a compromise may come out differently for males and females, as their resources and goals in life are different.”
Heisenberg’s team now intends to explore other questions, such as: How long does the flies’ depression-like state last? How does it affect other behaviors, like courtship and aggression? What is happening in their brain? And more.
Heisenberg says that the findings are a reminder of a lesson that children’s books are often best at showing: “Animals have lots in common with us humans. They breathe the same air, share many of the same resources, actively explore space, and have distinct social roles. Their brains serve the same purpose, too: they help them to do the right thing.”
HOLY SHIT THIS KID I WAS TALKING TO WAS LOOKING AT GOOGLE MAPS AND HE FOUND SOMEBODY DRAGGING A DEAD BODY IN TO A LAKE. 52.376552,5.198303 ARE THE COORDINATES I’M FREAKING OUT WHAT DO I DO
SOMEONE PLEASE EXPLAIN TO ME
THIS IS FUCKING CRAZY
That is just red wood that has been wet.
That is a dog that shook off the water and ran around.
Fruit flies may have more individuality and personality than we imagine.
And it might all be down to a bit of genetic shuffling in nerve cells that makes every fly brain unique, suggest Oxford University scientists.
Their new study has found that small genetic elements called ‘transposons’ are active in neurons in the fly brain. Transposons are also known as ‘jumping genes’, as these short scraps of DNA have the ability to move, cutting themselves out from one position in the genome and inserting themselves somewhere else.
The inherent randomness of the process is likely to make every fly brain unique, potentially providing behavioural individuality – or ‘fly personality’. So says Professor Scott Waddell, who led the work at the University of Oxford Centre for Neural Circuits and Behaviour: ‘We have known for some time that individual animals that are supposed to be genetically identical behave differently.
‘The extensive variation between fly brains that this mechanism could generate might demystify why some behave while others misbehave,’ he suggests.
The Oxford researchers, along with US colleagues at the University of Massachusetts Medical School and Howard Hughes Medical Institute, were able to deep-sequence the DNA from small numbers of nerve cells in the brains of Drosophila fruit flies.
They identified many transposons that were inserted in a number of important memory-related genes. Whether this is detrimental or advantageous to the fly remains an open question, the researchers say.
Scott Waddell notes that neural transposition has been described in rodent and human brains, and transposons have historically been considered to be problematic parasites. New insertions of transposons can on occasion disrupt genes (as was found in this study), and transposons have been associated to some human disorders such as schizophrenia.
However, it is also possible that organisms have harnessed transposition to generate variation within cells, and by extension create variation between individual animals that may turn out to be favourable.
Scott Waddell wants next to determine whether neural transposition provides an explanation for variation in fruit fly behaviour by finding ways of halting the process in flies in his lab.